Document 2017
 DOCN  M94A2017
 TI    Update on antiretroviral therapy.
 DT    9412
 AU    Vella S; Instituto Superiore di Sanita, Rome, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):4 (abstract no. PS3). Unique
       Identifier : AIDSLINE ICA10/94370558
 AB    The in vivo activity of the available anti-HIV compounds has been
       clearly demonstrated by the results in the treatment of advanced HIV
       disease and by the reduction of the vertical transmission rate. However,
       it is also evident that the efficacy of monotherapy is of limited
       duration, with drug-resistance probably playing a major role. With the
       new insights into the pathogenesis of HIV-disease suggesting the need
       for early intervention, and with the evidence that combination regimens
       are more effective in reducing HIV viral load, the results of large
       trials that clinically evaluate nucleoside combination regimens as
       first-line treatments are eagerly waited. In perspective, protease
       inhibitors which target a different virus enzyme and that have shown
       promising results in phase II studies, may also represent a major
       advance for combination regimens. In fact, the phenomenon of the
       selection of drug-resistant strains may be reduced by further reducing
       the HIV replication rate. Hopefully, the continuous progress in basic
       science and in drug development will ultimately lead to the
       identification of more efficient therapeutic strategies. However, a
       global cooperative action to ensure the availability and the
       accessibility of safe and effective drugs for developing countries
       should be regarded as one of the future priorities.
 DE    Antiviral Agents/*ADMINISTRATION & DOSAGE/SUPPLY & DISTRIBUTION/
       *THERAPEUTIC USE  Developing Countries  Drug Therapy, Combination  Human
       HIV/DRUG EFFECTS  HIV Infections/*DRUG THERAPY/METABOLISM  Protease
       Inhibitors/THERAPEUTIC USE  Virus Replication/DRUG EFFECTS  MEETING
       ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).